D-amino acid oxidase: physiological role and applications

Biochemistry (Mosc). 2008 Dec;73(13):1511-8. doi: 10.1134/s0006297908130105.


D-Amino acids play a key role in regulation of many processes in living cells. FAD-dependent D-amino acid oxidase (DAAO) is one of the most important enzymes responsible for maintenance proper level of D-amino acids. The most interesting and important data for regulation of the nervous system, hormone secretion, and other processes by D-amino acids as well as development of different diseases under changed DAAO activity are presented. The mechanism of regulation is complex and multi-parametric because the same enzyme simultaneously influences the level of different D-amino acids, which can result in opposing effects. Use of DAAO for diagnostic and therapeutic purposes is also considered.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Amino Acids / metabolism
  • Animals
  • D-Amino-Acid Oxidase / biosynthesis
  • D-Amino-Acid Oxidase / chemistry
  • D-Amino-Acid Oxidase / metabolism*
  • Eukaryotic Cells / metabolism
  • Humans
  • Saccharomycetales / enzymology


  • Amino Acids
  • D-Amino-Acid Oxidase