Entry of herpesviruses into cells: more than one way to pull the trigger

Structure. 2009 Feb 13;17(2):147-9. doi: 10.1016/j.str.2009.01.003.

Abstract

Interaction of viral protein gp42 with its receptor is the trigger for the entry of Epstein-Barr virus into B cells. The structure of gp42 reported by Kirschner etal. (2009) in this issue of Structure suggests a likely triggering mechanism substantially different from that of a related herpesvirus.

Publication types

  • Comment
  • News
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • B-Lymphocytes / virology*
  • Herpesviridae / physiology*
  • Herpesvirus 4, Human / metabolism
  • Herpesvirus 4, Human / physiology
  • Humans
  • Membrane Glycoproteins / metabolism
  • Membrane Glycoproteins / physiology
  • Models, Biological
  • Protein Binding
  • Virus Internalization*

Substances

  • Membrane Glycoproteins