Regulation of angiogenesis by oxygen and metabolism

Dev Cell. 2009 Feb;16(2):167-79. doi: 10.1016/j.devcel.2009.01.003.


Blood vessels form an important interface between the environment and the organism by carrying oxygen and nutrients to all cells and thus determining cellular metabolism. It is therefore not surprising that oxygen and metabolism influence the development of the vascular network. Here, we discuss recent insights regarding the emerging crosstalk between angiogenesis and metabolism. We will highlight advances in how oxygen and metabolism regulate angiogenesis as well as how angiogenic factors in turn also regulate metabolism.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Basic Helix-Loop-Helix Transcription Factors / metabolism
  • Blood Vessels / metabolism
  • Cell Lineage
  • Endothelial Cells / metabolism
  • Epigenesis, Genetic
  • Gene Expression Regulation, Developmental*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism
  • Mice
  • Models, Biological
  • Myocytes, Smooth Muscle / metabolism
  • Neovascularization, Pathologic*
  • Oxygen / metabolism*
  • Signal Transduction


  • Basic Helix-Loop-Helix Transcription Factors
  • HIF1A protein, human
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • endothelial PAS domain-containing protein 1
  • Oxygen