Flying podocytes

Kidney Int. 2009 Mar;75(5):455-7. doi: 10.1038/ki.2008.653.


Recent insights have defined the central role of podocytes both in rare genetic diseases and as a general determinant of the progression of human glomerular diseases. In a recent issue of Nature, Weavers et al. described a podocyte-like cell type in Drosophila, the nephrocyte, that closely resembles mammalian podocytes, including the nephrin-based slit diaphragm. This novel podocyte system might open new avenues toward the understanding of podocyte biology and pathophysiology.

MeSH terms

  • Animals
  • Basement Membrane
  • Drosophila melanogaster / anatomy & histology
  • Drosophila melanogaster / cytology*
  • Humans
  • Membrane Proteins
  • Podocytes / cytology*
  • Podocytes / metabolism
  • Podocytes / physiology
  • Signal Transduction


  • Membrane Proteins
  • nephrin