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Comparative Study
, 12 (3), 256-8

Beyond Extinction: Erasing Human Fear Responses and Preventing the Return of Fear

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Comparative Study

Beyond Extinction: Erasing Human Fear Responses and Preventing the Return of Fear

Merel Kindt et al. Nat Neurosci.

Abstract

Animal studies have shown that fear memories can change when recalled, a process referred to as reconsolidation. We found that oral administration of the beta-adrenergic receptor antagonist propranolol before memory reactivation in humans erased the behavioral expression of the fear memory 24 h later and prevented the return of fear. Disrupting the reconsolidation of fear memory opens up new avenues for providing a long-term cure for patients with emotional disorders.

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