Cerebral white matter hyperintensities are not increased in patients with primary Sjögren's syndrome

Eur J Neurol. 2009 May;16(5):576-81. doi: 10.1111/j.1468-1331.2009.02537.x. Epub 2009 Feb 11.


Background and purpose: It is frequently thought that cerebral white matter hyperintensities (WMHs) on T-2 weighted MRI scans are increased in patients with autoimmune diseases. An increased frequency of WHMs has been described in primary Sjögren's syndrome (PSS), but no controlled studies exist. The aim of this study was therefore to compare WMHs in PSS patients and healthy subjects applying the new European-American criteria for PSS.

Methods: Cross-sectional controlled study of 68 unselected PSS patients and 68 healthy subjects was carried out. WMHs were rated using Scheltens method.

Results: There were no differences in total or any regional WMH scores between PSS patients and healthy subjects.

Conclusions: Patients with PSS do not have increased WMH load or distribution when compared with healthy subjects.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brain / pathology*
  • Cross-Sectional Studies
  • Female
  • Humans
  • Magnetic Resonance Imaging
  • Male
  • Middle Aged
  • Neuropsychological Tests
  • Sjogren's Syndrome / pathology*
  • Sjogren's Syndrome / physiopathology