Clear cell fibrous papule: report of a case mimicking a balloon cell nevus

J Cutan Pathol. 2009 Mar;36(3):381-4. doi: 10.1111/j.1600-0560.2008.01038.x.


Clear cell fibrous papule (FP) is a rare variant of FP. We report a 39-year-old female patient who presented with a dome-shaped papule on the nose. The diagnosis of clear cell FP was made based on histological and immunohistochemical studies. Interestingly, scattered S-100 cells were admixed within the lesion, a finding hitherto not reported. The S-100 positivity may be misleading and should be cautiously interpreted.

MeSH terms

  • Adult
  • Diagnosis, Differential
  • Female
  • Humans
  • Neoplasm Proteins / metabolism
  • Nevus / metabolism
  • Nevus / pathology*
  • Nose Neoplasms / metabolism
  • Nose Neoplasms / pathology*
  • S100 Proteins / metabolism
  • Skin Neoplasms / metabolism
  • Skin Neoplasms / pathology*


  • Neoplasm Proteins
  • S100 Proteins