Mitotic kinase dynamics of the active form of AMPK (phospho-AMPKalphaThr172) in human cancer cells

Cell Cycle. 2009 Mar 1;8(5):788-91. doi: 10.4161/cc.8.5.7787. Epub 2009 Mar 6.

Abstract

When interrogating the activation status of AMP-activated protein kinase-measured as AMPKalpha(Thr172) phosphorylation-in tissue sections of human carcinomas and in cultured human cancer cells, the spatiotemporal dynamics of AMPK activity during the G(1)/S-to-M-phase transition strikingly resembles that of well-characterized "chromosomal passenger" proteins such as Aurora B, INCENP or Histone H3. The mitotic kinase behavior of the active form of AMPK may represent a candidate molecular link through which energy status directly influences tumorigenesis. A definitive elucidation of phospho-AMPKalpha(Thr172) in coordinating the chromosomal and cytoskeletal events of mitosis might radically amend our current perception of other AMPK-related diseases such as obesity, cardiac hypertrophy or accelerated aging syndromes.

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • AMP-Activated Protein Kinases / metabolism*
  • Aurora Kinase B
  • Aurora Kinases
  • Cell Line, Tumor
  • Chromosomal Proteins, Non-Histone / metabolism
  • G1 Phase
  • Histones / metabolism
  • Humans
  • Mitosis*
  • Neoplasms / enzymology*
  • Phosphorylation
  • Protein-Serine-Threonine Kinases / metabolism
  • S Phase

Substances

  • Chromosomal Proteins, Non-Histone
  • Histones
  • INCENP protein, human
  • AURKB protein, human
  • Aurora Kinase B
  • Aurora Kinases
  • Protein-Serine-Threonine Kinases
  • AMP-Activated Protein Kinases