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. 2009;37(1):159-67.
doi: 10.1142/S0192415X09006746.

Estrogen Activities and the Cellular Effects of Natural Progesterone From Wild Yam Extract in mcf-7 Human Breast Cancer Cells

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Estrogen Activities and the Cellular Effects of Natural Progesterone From Wild Yam Extract in mcf-7 Human Breast Cancer Cells

Mi-Kyung Park et al. Am J Chin Med. .

Abstract

We studied the estrogenic activity and cellular effect of wild yam extract in MCF-7 human breast cancer cells. The extract increased the activity of the progesterone receptor and pS2 genes at the mRNA levels in human breast cancer MCF-7 cells, although the effects were not as prominent as those of 17beta-estradiol (E(2)). Western blot analysis showed that the level of estrogen receptor alpha protein was down-regulated after treatment with E(2) or wild yam extract. Wild yam extract also inhibited proliferation of MCF-7 cells. These data indicate that wild yam extract acts as a weak phytoestrogen and protects against proliferation in human breast carcinoma MCF-7 cells.

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