Pathology type does not predict language lateralization in children with medically intractable epilepsy

Epilepsia. 2009 Jun;50(6):1498-504. doi: 10.1111/j.1528-1167.2008.02014.x. Epub 2009 Feb 13.


Purpose: We examined potential differences in the effects of pathology type on language lateralization in pediatric epilepsy.

Methods: We examined findings from intracarotid sodium amobarbital procedure (IAP/Wada) in a large consecutive sample of children with refractory epilepsy. Subjects were assigned to one of three pathology groups: developmental (n = 28), acquired (n = 26), and tumor (n = 20); groups were compared for language lateralization.

Results: Rates of atypical language lateralization did not differ across groups. Greater than half of the subjects with left hemisphere insults and seizure onset before 6 years of age had atypical language lateralization, independent of pathology type.

Discussion: Atypical language lateralization may occur in the context of developmental, acquired, and/or tumor pathology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Chi-Square Distribution
  • Child
  • Electroencephalography / methods
  • Epilepsy / complications*
  • Epilepsy / pathology*
  • Female
  • Functional Laterality / physiology*
  • Humans
  • Language Disorders / classification
  • Language Disorders / etiology*
  • Language Disorders / pathology*
  • Language Tests
  • Male