Successful use of inhaled nitric oxide to decrease intracranial pressure in a patient with severe traumatic brain injury complicated by acute respiratory distress syndrome: a role for an anti-inflammatory mechanism?

Scand J Trauma Resusc Emerg Med. 2009 Feb 17:17:5. doi: 10.1186/1757-7241-17-5.


Use of inhaled nitric oxide in humans with traumatic brain injury and acute respiratory distress syndrome has twice previously been reported to be beneficial. Here we report a third case. We propose that INO may decrease the inflammatory response in patients with increased intracranial pressure caused by traumatic brain injury accompanied by acute respiratory distress syndrome thereby contributing to improved outcomes.

Publication types

  • Case Reports

MeSH terms

  • Accidents, Traffic
  • Adult
  • Anti-Inflammatory Agents
  • Brain Injuries / drug therapy
  • Brain Injuries / physiopathology*
  • Free Radical Scavengers / administration & dosage
  • Free Radical Scavengers / pharmacology*
  • Humans
  • Intracranial Pressure / drug effects*
  • Male
  • Nitric Oxide / administration & dosage
  • Nitric Oxide / pharmacology*
  • Respiratory Distress Syndrome / complications*


  • Anti-Inflammatory Agents
  • Free Radical Scavengers
  • Nitric Oxide