Upregulation of HAb18G/CD147 in activated human umbilical vein endothelial cells enhances the angiogenesis

Cancer Lett. 2009 Jun 8;278(1):113-21. doi: 10.1016/j.canlet.2009.01.004. Epub 2009 Feb 14.


Previous studies demonstrated that CD147 molecule, highly expressed on the surface of various malignant tumor cells, significantly correlated with the malignancy of these cancers; however, the role of HAb18G/CD147 in endothelial cells has yet to be established. In this study, we found that the expression of HAb18G/CD147 was significantly upregulated in activated HUVECs. The inhibition of HAb18G/CD147 expression by specific siRNA led to significantly decreased angiogenesis in vitro. Our data indicate that HAb18G/CD147 may regulate angiogenesis via several mechanisms including proliferation, survival, migration, MMPs secretion, and PI3K/Akt activation. Our findings for the first time suggest that upregulation of HAb18G/CD147 in activated HUVECs might play an important role in angiogenesis.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antigens, CD / genetics
  • Basigin / genetics*
  • Cell Movement
  • Endothelium, Vascular / cytology
  • Endothelium, Vascular / physiology*
  • Flow Cytometry
  • Humans
  • In Situ Nick-End Labeling
  • Neoplasms / genetics
  • Neovascularization, Pathologic / genetics
  • Neovascularization, Physiologic / genetics*
  • RNA, Small Interfering / genetics
  • Umbilical Veins / cytology
  • Umbilical Veins / physiology*
  • Up-Regulation*


  • Antigens, CD
  • BSG protein, human
  • RNA, Small Interfering
  • Basigin