Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)

Srdjan Djurovic; Stephanie Le Hellard; Anna K Kähler; Erik G Jönsson; Ingrid Agartz; Vidar M Steen; Håkan Hall; August G Wang; Henrik B Rasmussen; Ingrid Melle; Thomas Werge; Ole A Andreassen

doi:10.1016/j.psychres.2008.08.007

Association of MCTP2 gene variants with schizophrenia in three independent samples of Scandinavian origin (SCOPE)

Psychiatry Res. 2009 Aug 15;168(3):256-8. doi: 10.1016/j.psychres.2008.08.007. Epub 2009 Feb 15.

Authors

Srdjan Djurovic¹, Stephanie Le Hellard, Anna K Kähler, Erik G Jönsson, Ingrid Agartz, Vidar M Steen, Håkan Hall, August G Wang, Henrik B Rasmussen, Ingrid Melle, Thomas Werge, Ole A Andreassen

Affiliation

¹ Institute of Psychiatry, University of Oslo, Norway. srdjan.djurovic@medisin.uio.no

PMID: 19223264
DOI: 10.1016/j.psychres.2008.08.007

Abstract

The MCTP2 gene is involved in intercellular signal transduction and synapse function. We genotyped 37 tagging SNPs across the MCTP2 gene to study a possible association with schizophrenia in three independent Scandinavian samples. We report, for the first time, a possible involvement of MCTP2 as a potential novel susceptibility gene for schizophrenia.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Female
Gene Frequency
Genetic Predisposition to Disease*
Genome-Wide Association Study
Genotype
Humans
Male
Membrane Proteins / genetics*
Polymorphism, Single Nucleotide / genetics*
Scandinavian and Nordic Countries
Schizophrenia / genetics*

Substances

MCTP2 protein, human
Membrane Proteins