Identification of self peptides bound to purified HLA-B27

Nature. 1991 Sep 26;353(6342):326-9. doi: 10.1038/353326a0.


A pool of endogenous peptides bound to the human class I MHC molecule, HLA-B27, has been isolated. Microsequence analysis of the pool and of 11 HPLC-purified peptides provides information on the binding specificity of the HLA-B27 molecule. The peptides all seem to be nonamers, seven of which match to protein sequences in a database search. These self peptides derive from abundant cytosolic or nuclear proteins, such as histone, ribosomal proteins, and members of the 90K heat-shock protein family.

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Chromatography, High Pressure Liquid / methods
  • HLA-B27 Antigen / metabolism*
  • Humans
  • Molecular Sequence Data
  • Peptides / chemistry*
  • Peptides / isolation & purification
  • Peptides / metabolism
  • Protein Binding
  • Sequence Homology, Nucleic Acid


  • HLA-B27 Antigen
  • Peptides