Sequence similarity between the mammalian bmi-1 proto-oncogene and the Drosophila regulatory genes Psc and Su(z)2

Nature. 1991 Sep 26;353(6342):353-5. doi: 10.1038/353353a0.


The bmi-1 proto-oncogene can be activated by Moloney murine leukaemia proviral insertions in E mu-myc transgenic mice. It encodes a highly conserved nuclear protein of 324 amino acids which belongs to a family of proteins containing a putative new zinc-finger. Another closely related member of this family is the mouse protein Mel-18. Here we report on the cloning and characterization of a homologous gene (D-bmi) from Drosophila melanogaster. Our analysis indicates that distinct domains of the mouse Bmi-1 protein, including the putative zinc-finger motif, are highly conserved within the much larger D-Bmi protein. Chromosomal localization and sequence comparison reveal that D-bmi is identical to Posterior Sex Combs (Psc) and indicate that the conserved domains between mouse bmi and Psc are also conserved within Suppressor-2 of Zeste (Su(z)2).

MeSH terms

  • Amino Acid Sequence
  • Animals
  • Drosophila melanogaster / genetics*
  • Genes, Regulator*
  • Mice
  • Molecular Sequence Data
  • Mutation
  • Nucleic Acid Hybridization
  • Phenotype
  • Proto-Oncogenes*
  • Sequence Homology, Nucleic Acid