Prognostic value of prostate circulating cells detection in prostate cancer patients: a prospective study

Br J Cancer. 2009 Feb 24;100(4):608-10. doi: 10.1038/sj.bjc.6604912.


In clinically organ-confined prostate cancer patients, bloodstream tumour cell dissemination generally occurs, and may be enhanced by surgical prostate manipulation. To evaluate cancer-cell seeding impact upon patient recurrence-free survival, 155 patients were prospectively enrolled then followed. Here, 57 patients presented blood prostate cell shedding preoperatively and intraoperatively (group I). Of the 98 preoperatively negative patients, 53 (54%) remained negative (group II) and 45 (46%) became intraoperatively positive (group III). Median biological and clinical recurrence-free time was far shorter in group I (36.2 months, P<0.0001) than in group II (69.6 months) but did not significantly differ in group II and III (69.6 months vs 65.0). Such 5-year follow-up data show that preoperative circulating prostate cells are an independent prognosis factor of recurrence. Moreover, tumour handling induces cancer-cell seeding but surgical blood dissemination does not accelerate cancer evolution.

MeSH terms

  • Aged
  • Follow-Up Studies
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local / blood
  • Neoplasm Staging
  • Neoplastic Cells, Circulating*
  • Prognosis
  • Prospective Studies
  • Prostatic Neoplasms / diagnosis*
  • Prostatic Neoplasms / pathology*
  • Prostatic Neoplasms / surgery