The management of amyotrophic lateral sclerosis

J Neurol. 2009 Feb;256(2):176-86. doi: 10.1007/s00415-009-0142-9. Epub 2009 Feb 17.

Abstract

The terms amyotrophic lateral sclerosis (ALS) or motor neuron disease (MND) refer to a condition characterized by motor system degeneration with relative preservation of other pathways. Although there have been advances in symptomatic treatment, ALS remains an incurable condition. Advances in ALS management prolong survival but simultaneously raise challenging ethical dilemmas for physicians, patients and their families. Here, we review current practice in the management of ALS including pharmacological treatment, nutritional management, respiratory care, and evolving strategies in the management of cognitive impairment.

Publication types

  • Review

MeSH terms

  • Amyotrophic Lateral Sclerosis / complications
  • Amyotrophic Lateral Sclerosis / psychology
  • Amyotrophic Lateral Sclerosis / therapy*
  • Caregivers / ethics
  • Caregivers / psychology
  • Caregivers / statistics & numerical data
  • Cognition Disorders / etiology
  • Cognition Disorders / psychology
  • Cognition Disorders / therapy*
  • Genetic Predisposition to Disease / genetics
  • Long-Term Care / ethics
  • Long-Term Care / methods
  • Long-Term Care / psychology
  • Palliative Care / methods
  • Palliative Care / standards
  • Physician-Patient Relations / ethics
  • Respiration, Artificial / standards
  • Respiratory Insufficiency / etiology
  • Respiratory Insufficiency / physiopathology
  • Respiratory Insufficiency / therapy
  • Withholding Treatment / ethics
  • Withholding Treatment / standards