Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
, 108 (3), 759-69

Noninfectious Serious Hazards of Transfusion

Affiliations
Review

Noninfectious Serious Hazards of Transfusion

Jeanne E Hendrickson et al. Anesth Analg.

Abstract

As infectious complications from blood transfusion have decreased because of improved donor questionnaires and sophisticated infectious disease blood screening, noninfectious serious hazards of transfusion (NISHOTs) have emerged as the most common complications of transfusion. The category of NISHOTs is very broad, including everything from well-described and categorized transfusion reactions (hemolytic, febrile, septic, and allergic/urticarial/anaphylactic) to lesser known complications. These include mistransfusion, transfusion-related acute lung injury, transfusion-associated circulatory overload, posttransfusion purpura, transfusion-associated graft versus host disease, microchimerism, transfusion-related immunomodulation, alloimmunization, metabolic derangements, coagulopathic complications of massive transfusion, complications from red cell storage lesions, complications from over or undertransfusion, and iron overload. In recent years, NISHOTs have attracted more attention than ever before, both in the lay press and in the scientific community. As the list of potential complications from blood transfusion grows, investigators have focused on the morbidity and mortality of liberal versus restrictive red blood cell transfusion, as well as the potential dangers of transfusing "older" versus "younger" blood. In this article, we review NISHOTs, focusing on the most recent concerns and literature.

Similar articles

  • Noninfectious Serious Hazards of Transfusion
    K Janatpour et al. Curr Hematol Rep 1 (2), 149-55. PMID 12901137. - Review
    Serious, noninfectious transfusion complications include transfusion-related acute lung injury (TRALI), transfusion-associated graft-versus-host disease, anaphylaxis, hem …
  • Reducing Noninfectious Risks of Blood Transfusion
    BM Gilliss et al. Anesthesiology 115 (3), 635-49. PMID 21792054. - Review
    As screening for transfusion-associated infections has improved, noninfectious complications of transfusion now cause the majority of morbidity and mortality associated w …
  • Non-infectious Complications of Transfusion Therapy
    PL Perrotta et al. Blood Rev 15 (2), 69-83. PMID 11409907. - Review
    Blood transfusion is considered safe when the infused blood is tested using state of the art viral assays developed over the past several decades. Only rarely are known v …
  • Transfusion of Blood and Blood Products: Indications and Complications
    S Sharma et al. Am Fam Physician 83 (6), 719-24. PMID 21404983. - Review
    Red blood cell transfusions are used to treat hemorrhage and to improve oxygen delivery to tissues. Transfusion of red blood cells should be based on the patient's clinic …
  • Common Reactions to Transfusions
    D Gloe. Heart Lung 20 (5 Pt 1), 506-12. PMID 1894531.
    A blood transfusion is a special kind of transplantation, with the transfer of living tissue from one person to another. Reactions can occur with as little as 10 to 15 ml …
See all similar articles

Cited by 84 PubMed Central articles

See all "Cited by" articles
Feedback