Association of circulating adhesion molecules with lung function. The CARDIA study

Chest. 2009 Jun;135(6):1481-1487. doi: 10.1378/chest.08-1753. Epub 2009 Feb 18.


Background: Systemic inflammation has been associated with reduced lung function. Adhesion molecules, such as intercellular adhesion molecule (ICAM)-1 and P-selectin, figure importantly in initiating the inflammatory response. We studied the association between ICAM-1 and P-selectin concentrations and lung function in the Coronary Artery Risk Development in Young Adults study.

Methods: Spirometry testing was conducted at years 5, 10, and 20. ICAM-1 and P-selectin were assayed at year 15.

Results: Complete data were obtained from 2,455 participants. We first predicted year-20 lung function from year-15 ICAM-1 concentration data. After controlling for race, gender, height, age, physical activity, smoking status, alcohol intake, BMI, and asthma status, all taken at year 15, the year-20 FVC was 164 mL higher (p < 0.0001) and FEV(1) was 164 mL higher (p = 0.0003) in the lowest ICAM-1 concentration quartile than the highest ICAM-1 quartile, whereas the FEV(1)/FVC ratio showed no association (p = 0.25). We then predicted the year-15 ICAM-1 concentration from year-5 lung function and change in lung function (year 10 - year 5). The year-15 ICAM-1 concentration was about 13 ng/mL higher in the lowest vs highest quartile of either the year-5 FVC (p = 0.01) or year-5 FEV(1) (p = 0.005). Year-15 ICAM-1 concentration was unrelated to year-5 FEV(1)/FVC ratio. Greater loss in FVC and FEV(1) (year 10 - year 5) also was associated with higher year-15 ICAM-1 concentrations. Associations between P-selectin and lung function followed a similar but weaker pattern to that observed for ICAM-1.

Conclusions: These data suggest a bidirectional association between circulating adhesion molecules, such as ICAM-1 and P-selectin, and pattern of lung function change in adults.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adolescent
  • Adult
  • Age Factors
  • Cohort Studies
  • Disease Progression
  • Female
  • Forced Expiratory Volume
  • Humans
  • Inflammation / blood
  • Inflammation / physiopathology
  • Inflammation Mediators / blood*
  • Intercellular Adhesion Molecule-1 / blood*
  • Lung Diseases / blood
  • Lung Diseases / physiopathology*
  • Male
  • P-Selectin / blood*
  • Predictive Value of Tests
  • Registries
  • Respiratory Function Tests
  • Risk Assessment
  • Sensitivity and Specificity
  • Severity of Illness Index
  • Young Adult


  • Inflammation Mediators
  • P-Selectin
  • Intercellular Adhesion Molecule-1