Serum interleukin-17 levels are related to clinical severity in allergic rhinitis

Allergy. 2009 Sep;64(9):1375-8. doi: 10.1111/j.1398-9995.2009.02010.x. Epub 2009 Feb 17.


Background: T helper (Th)-17 cells are a subset of T helper lymphocytes that exert regulatory activities. Recently, it has been reported that serum interleukin (IL)-17 levels are high in the most severe cases of birch allergy studied outside the pollen season.

Objective: The aim of this study was to investigate a possible relationship between serum IL-17 levels and clinical parameters in patients with allergic rhinitis studied during the pollen season.

Methods: In all, 56 patients with persistent pollen-induced allergic rhinitis were evaluated during the pollen season. Serum IL-17 levels were evaluated by enzyme-linked immunosorbent assay. Symptoms were assessed by visual analogue scale, drug use was monitored and peripheral eosinophils were counted.

Results: Serum IL-17 levels were significantly related to clinical symptoms, drug use and peripheral eosinophil counts (P = 0.0001 for all).

Conclusion: This study provides evidence that serum IL-17 level assessment might be considered to classify allergy severity.

MeSH terms

  • Adult
  • Allergens / immunology
  • Betula / immunology
  • Cell Count
  • Eosinophils / immunology
  • Female
  • Humans
  • Interleukin-17 / blood*
  • Male
  • Pollen / immunology
  • Rhinitis, Allergic, Seasonal / blood
  • Rhinitis, Allergic, Seasonal / diagnosis
  • Rhinitis, Allergic, Seasonal / immunology*
  • Severity of Illness Index*
  • T-Lymphocytes, Helper-Inducer / immunology*
  • T-Lymphocytes, Helper-Inducer / metabolism


  • Allergens
  • Interleukin-17