Ketamine/xylazine anesthesia alters [11C]MNPA binding to dopamine D2 receptors and response to methamphetamine challenge in monkey brain

Synapse. 2009 Jun;63(6):534-7. doi: 10.1002/syn.20632.
No abstract available

MeSH terms

  • Adrenergic alpha-Agonists / pharmacology
  • Anesthetics, Dissociative / pharmacology
  • Animals
  • Apomorphine / analogs & derivatives*
  • Apomorphine / metabolism
  • Binding, Competitive / drug effects*
  • Binding, Competitive / physiology
  • Brain / drug effects
  • Brain / metabolism
  • Brain / physiopathology
  • Brain Chemistry / drug effects
  • Brain Chemistry / physiology
  • Carbon Radioisotopes
  • Corpus Striatum / drug effects
  • Corpus Striatum / metabolism
  • Dopamine Uptake Inhibitors / pharmacology
  • Drug Interactions / physiology
  • Ketamine / pharmacology*
  • Macaca mulatta
  • Male
  • Methamphetamine / pharmacology*
  • Receptors, Dopamine D2 / drug effects*
  • Receptors, Dopamine D2 / metabolism
  • Synaptic Transmission / drug effects
  • Synaptic Transmission / physiology
  • Xylazine / pharmacology*

Substances

  • Adrenergic alpha-Agonists
  • Anesthetics, Dissociative
  • Carbon Radioisotopes
  • Dopamine Uptake Inhibitors
  • Receptors, Dopamine D2
  • 2-methoxy-N-n-propylnorapomorphine
  • Xylazine
  • Methamphetamine
  • Ketamine
  • Apomorphine