Down syndrome: a cardiovascular perspective

J Intellect Disabil Res. 2009 May;53(5):419-25. doi: 10.1111/j.1365-2788.2009.01158.x. Epub 2009 Feb 18.


This review focuses on the heart and vascular system in patients with Down syndrome. A clear knowledge on the wide spectrum of various abnormalities associated with this syndrome is essential for skillful management of cardiac problems in patients with Down syndrome. Epidemiology of congenital heart defects, cardiovascular aspects and thyroid-related cardiac impairment in patients with Down syndrome will be discussed.

Publication types

  • Review

MeSH terms

  • Chromosomes, Human, Pair 22 / genetics
  • Coronary Artery Disease / epidemiology*
  • Down Syndrome / epidemiology*
  • Down Syndrome / genetics
  • Ductus Arteriosus, Patent / epidemiology*
  • Heart Defects, Congenital / epidemiology*
  • Heart Septal Defects, Atrial / epidemiology*
  • Humans
  • Life Expectancy
  • Prevalence