Ultrasome: efficient aberration caller for copy number studies of ultra-high resolution

Bioinformatics. 2009 Apr 15;25(8):1078-9. doi: 10.1093/bioinformatics/btp091. Epub 2009 Feb 19.


Motivation: Multimillion-probe microarrays allow detection of gains and losses of chromosomal material at unprecedented resolution. However, the data generated by these arrays are several-fold larger than data from earlier platforms, creating a need for efficient analysis tools that scale robustly with data size.

Results: We developed a new aberration caller, Ultrasome, that delineates genomic changes-of-interest with dramatically improved efficiency. Ultrasome shows near-linear computational complexity and processes latest generation copy number arrays about 10,000 times faster than standard methods with preserved analytic accuracy.

MeSH terms

  • Algorithms
  • Chromosome Aberrations*
  • Computational Biology / methods*
  • Gene Dosage
  • Gene Expression Profiling
  • Oligonucleotide Array Sequence Analysis / methods*
  • Polymorphism, Single Nucleotide