Pathogenicity of highly pathogenic avian influenza virus in mammals

Vaccine. 2008 Sep 12;26 Suppl 4(Suppl 4):D54-8. doi: 10.1016/j.vaccine.2008.07.072.


In recent years, there has been an increase in outbreaks of highly pathogenic avian influenza (HPAI) in poultry. Occasionally, these outbreaks have resulted in transmission of influenza viruses to humans and other mammals, with symptoms ranging from conjunctivitis to pneumonia and death. Here, the current knowledge of the determinants of pathogenicity of HPAI viruses in mammals is summarized. It is becoming apparent that common mechanisms exist across influenza A virus strains and subtypes, through which influenza viruses adapt to mammals and gain or loose pathogenicity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Influenza A virus / genetics
  • Influenza A virus / pathogenicity*
  • Influenza in Birds / epidemiology*
  • Influenza in Birds / transmission
  • Influenza in Birds / virology*
  • Mammals
  • Poultry
  • Virulence Factors*


  • Virulence Factors