A case of optic neuropathy after short-term linezolid use in a patient with acute lymphocytic leukemia

Clin Infect Dis. 2009 Apr 1;48(7):e73-4. doi: 10.1086/597298.


A patient undergoing chemotherapy for treatment of acute lymphocytic leukemia developed septicemia that was treated with linezolid for 16 days. The patient subsequently reported reduced vision in both eyes and was found to have bilateral optic neuropathy. After the discontinuation of linezolid treatment, both the optic neuropathy and visual impairment resolved without sequelae.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acetamides / adverse effects*
  • Acetamides / therapeutic use
  • Adult
  • Anti-Bacterial Agents / adverse effects*
  • Anti-Bacterial Agents / therapeutic use
  • Female
  • Humans
  • Linezolid
  • Optic Nerve Diseases / chemically induced*
  • Oxazolidinones / adverse effects*
  • Oxazolidinones / therapeutic use
  • Precursor Cell Lymphoblastic Leukemia-Lymphoma / complications*
  • Sepsis / drug therapy*
  • Young Adult


  • Acetamides
  • Anti-Bacterial Agents
  • Oxazolidinones
  • Linezolid