Developments in the clinical understanding of osteoarthritis

Arthritis Res Ther. 2009;11(1):203. doi: 10.1186/ar2531. Epub 2009 Jan 30.


With the recognition that osteoarthritis is a disease of the whole joint, attention has focused increasingly on features in the joint environment which cause ongoing joint damage and are likely sources of pain. This article reviews current ways of assessing osteoarthritis progression and what factors potentiate it, structural abnormalities that probably produce pain, new understandings of the genetics of osteoarthritis, and evaluations of new and old treatments.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Clinical Trials as Topic
  • Disease Progression
  • Humans
  • Osteoarthritis / genetics*
  • Osteoarthritis / pathology*
  • Osteoarthritis / therapy*
  • Risk Factors