Alterations in the Intestinal Microbiota and Functional Bowel Symptoms

Gastrointest Endosc Clin N Am. 2009 Jan;19(1):141-50, vii. doi: 10.1016/j.giec.2008.12.004.


Functional gastrointestinal disorders (FGIDs) are highly prevalent in Western countries yet no single mechanism or etiological agent that initiates IBS has been identified. Current research has implicated the intestinal microbiota with FGIDs. This article reviews the available literature/data regarding the intestinal microbiota and FGIDS. The possible relationships between the intestinal microbiota and the intestinal function and functional bowel symptoms are discussed.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Bacterial Agents / therapeutic use
  • Colonic Diseases, Functional / drug therapy
  • Colonic Diseases, Functional / epidemiology
  • Colonic Diseases, Functional / microbiology*
  • Gastrointestinal Tract / drug effects
  • Gastrointestinal Tract / microbiology*
  • Gastrointestinal Tract / pathology
  • Humans
  • Irritable Bowel Syndrome / drug therapy
  • Irritable Bowel Syndrome / epidemiology
  • Irritable Bowel Syndrome / microbiology
  • Prevalence
  • Probiotics / therapeutic use
  • United States / epidemiology


  • Anti-Bacterial Agents