Efficacy of intralesional 5-fluorouracil and triamcinolone in the treatment of keloids

Aesthet Surg J. Jan-Feb 2009;29(1):40-6. doi: 10.1016/j.asj.2008.11.006.

Abstract

Background: Keloids are a common problem with significant recurrence rates despite intralesional steroid treatment and multimodal therapy.

Objective: The purpose of this study was to evaluate the efficacy of using a 5-fluorouracil (5-FU)/steroid mixture to treat keloids over the past 7 years, comparing the results with use of steroid treatment alone.

Methods: Patient charts from 1999 to 2006 were reviewed. Patients were stratified into 3 groups: (1) 5-FU/steroid without excision; (2) 5-FU/steroid with excision; and (3) steroid treatment with excision. The percentage of lesion size reduction and symptoms were evaluated.

Results: A total of 102 keloids were identified in a retrospective review. Patients who underwent the 5-FU/steroid combination with excision had a 92% average reduction in lesion size compared with 73% in the group of patients who did not receive 5-FU. Patients who received 5-FU/steroid without excision had an average lesion size reduction of 81%. Differences in complication rates were not statistically significant.

Conclusions: Combination 5-FU/triamcinolone is superior to intralesional steroid therapy in the treatment of keloids.

Publication types

  • Comparative Study
  • Evaluation Study

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Analysis of Variance
  • Anti-Inflammatory Agents / administration & dosage*
  • Combined Modality Therapy / methods
  • Drug Therapy, Combination
  • Female
  • Fluorouracil / administration & dosage*
  • Follow-Up Studies
  • Humans
  • Immunosuppressive Agents / administration & dosage*
  • Injections, Intralesional / methods
  • Keloid / drug therapy*
  • Keloid / surgery
  • Male
  • Middle Aged
  • Recurrence
  • Retrospective Studies
  • Treatment Outcome
  • Triamcinolone / administration & dosage*

Substances

  • Anti-Inflammatory Agents
  • Immunosuppressive Agents
  • Triamcinolone
  • Fluorouracil