The Wisconsin Epidemiologic Study of Diabetic Retinopathy. XIII. Relationship of serum cholesterol to retinopathy and hard exudate

Ophthalmology. 1991 Aug;98(8):1261-5. doi: 10.1016/s0161-6420(91)32145-6.

Abstract

Serum total and high-density lipoprotein (HDL) cholesterol were measured in a sample of individuals examined between 1984 and 1986 for the Wisconsin Epidemiologic Study of Diabetic Retinopathy. There was a significant trend for increasing severity of diabetic retinopathy and of retinal hard exudate with increasing cholesterol in insulin-using persons. Cholesterol levels were not related to the severity of either ocular condition in older-onset patients. High-density lipoprotein-cholesterol was unrelated to the severity of either lesion. In multiple logistic regression analyses, cholesterol was not a significant factor in describing the severity of retinopathy in any group but was a significant factor in describing the severity of retinal hard exudate. Glycosylated hemoglobin and diastolic blood pressure were significant descriptors of the severity of retinopathy in younger-onset patients in these multivariate analyses. Diastolic blood pressure added significantly to explaining the severity of hard exudate in older-onset insulin users. These data support the current management strategies for diabetes, which include control of level of glycemia, blood pressure, and blood lipids.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Adult
  • Aged
  • Blood Pressure
  • Cholesterol / blood*
  • Cholesterol, HDL / blood*
  • Diabetes Mellitus / drug therapy
  • Diabetic Retinopathy / blood*
  • Diabetic Retinopathy / epidemiology
  • Diabetic Retinopathy / etiology
  • Exudates and Transudates
  • Glycated Hemoglobin A / analysis
  • Humans
  • Insulin / therapeutic use
  • Middle Aged
  • Odds Ratio
  • Wisconsin / epidemiology

Substances

  • Cholesterol, HDL
  • Glycated Hemoglobin A
  • Insulin
  • Cholesterol