IL-17F: Regulation, Signaling and Function in Inflammation

Cytokine. 2009 Apr;46(1):7-11. doi: 10.1016/j.cyto.2008.12.024. Epub 2009 Feb 23.

Abstract

The IL-17 cytokine family is composed of six members. IL-17F, discovered in 2001, recently has drawn increasing attention due to its greatest similarity to IL-17, a widely recognized inflammatory cytokine. The genes encoding IL-17 and IL-17F are localized in the same chromosomal region and are co-expressed by CD4+ and gammadelta T cells. IL-17F can be secreted as homodimers or heterodimers with IL-17. Similar to IL-17, IL-17F utilizes IL-17RA and IL-17RC as its receptor and employs Act1 and TRAF6 as its signal transducers to induce the expression of pro-inflammatory cytokines and chemokines in many different cell types. However, mice lacking either IL-17 or IL-17F exhibit distinct defects in experimental models of asthma and colitis. These results have laid the basis to understand the role of IL-17F in the pathogenesis of human diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Autoimmune Diseases / metabolism
  • CD4-Positive T-Lymphocytes / metabolism
  • Cytokines / metabolism
  • Dimerization
  • Gene Expression Regulation*
  • Humans
  • Inflammation / metabolism*
  • Interleukin-17 / genetics
  • Interleukin-17 / metabolism
  • Interleukin-17 / physiology*
  • Intestinal Mucosa / metabolism
  • Models, Biological
  • Neurons / metabolism
  • Signal Transduction
  • TNF Receptor-Associated Factor 6 / metabolism
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins / metabolism

Substances

  • Cytokines
  • Interleukin-17
  • TNF Receptor-Associated Factor 6
  • TRAF3IP2 protein, human
  • Tumor Necrosis Factor Receptor-Associated Peptides and Proteins