Abstract
The mammalian SWI/SNF complexes mediate ATP-dependent chromatin remodeling processes that are critical for differentiation and proliferation. Not surprisingly, loss of SWI/SNF function has been associated with malignant transformation, and a substantial body of evidence indicates that several components of the SWI/SNF complexes function as tumor suppressors. This review summarizes the evidence that underlies this conclusion, with particular emphasis upon the two catalytic subunits of the SWI/SNF complexes, BRM, the mammalian ortholog of SWI2/SNF2 in yeast and brahma in Drosophila, and Brahma-related gene-1 (BRG1).
MeSH terms
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Adenosine Triphosphate / physiology
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Animals
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Cell Adhesion
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Cell Differentiation
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Chromatin Assembly and Disassembly
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Chromosomal Proteins, Non-Histone / genetics
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Chromosomal Proteins, Non-Histone / physiology*
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DNA Helicases / chemistry
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DNA Helicases / genetics
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DNA Helicases / physiology*
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DNA Repair
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology
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Gene Expression Regulation
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Gene Silencing
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Humans
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Immune System / physiology
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Loss of Heterozygosity
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Neoplasms / genetics*
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Nuclear Proteins / chemistry
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Nuclear Proteins / genetics
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Nuclear Proteins / physiology*
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SMARCB1 Protein
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Transcription Factors / chemistry
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Transcription Factors / genetics
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Transcription Factors / physiology*
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Tumor Suppressor Proteins / physiology
Substances
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Chromosomal Proteins, Non-Histone
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DNA-Binding Proteins
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Nuclear Proteins
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PBRM1 protein, human
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SMARCA2 protein, human
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SMARCB1 Protein
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SMARCB1 protein, human
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SWI-SNF-B chromatin-remodeling complex
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Transcription Factors
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Tumor Suppressor Proteins
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Adenosine Triphosphate
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SMARCA4 protein, human
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DNA Helicases