A novel three-component reaction for the synthesis of 3-aryl-4H-benzo [1,4] oxazin-2-amine

Mol Divers. 2009 Aug;13(3):395-8. doi: 10.1007/s11030-009-9126-z. Epub 2009 Feb 21.

Abstract

A high yielding and fast method for the synthesis of 3-aryl-4H-benzo [1,4] oxazin-2-amine via one-pot, three component reaction of an aromatic aldehyde, isocyanide and o-aminophenol using p-toluene sulfonic acid as a catalyst is described.

MeSH terms

  • Aldehydes / chemistry
  • Amines / chemistry
  • Aminophenols / chemistry
  • Benzenesulfonates / chemistry*
  • Benzoxazines / chemical synthesis*
  • Benzoxazines / chemistry
  • Cyanides / chemistry

Substances

  • Aldehydes
  • Amines
  • Aminophenols
  • Benzenesulfonates
  • Benzoxazines
  • Cyanides
  • 4-toluenesulfonic acid