Reprint: Good laboratory practice: preventing introduction of bias at the bench

Int J Stroke. 2009 Feb;4(1):3-5. doi: 10.1111/j.1747-4949.2009.00241.x.


As a research community, we have failed to demonstrate that drugs that show substantial efficacy in animal models of cerebral ischemia can also improve outcome in human stroke. Accumulating evidence suggests that this may be due, at least in part, to problems in the design, conduct and reporting of animal experiments, which create a systematic bias resulting in the overstatement of neuroprotective efficacy. Here, we set out a series of measures to reduce bias in the design, conduct and reporting of animal experiments modeling human stroke.

MeSH terms

  • Animals
  • Bias*
  • Biomedical Research / methods
  • Biomedical Research / standards*
  • Disease Models, Animal
  • Guidelines as Topic / standards*
  • Humans
  • Neuroprotective Agents / pharmacology*
  • Research Design / standards*
  • Stroke / drug therapy*


  • Neuroprotective Agents