Prolonged intrahepatic cholestasis and renal failure secondary to anabolic androgenic steroid-enriched dietary supplements

J Clin Gastroenterol. 2009 Aug;43(7):672-5. doi: 10.1097/MCG.0b013e318188be6d.


The illegal enrichment of anabolic androgenic steroids in over-the-counter dietary supplements is well documented, but the health consequences have not been widely recognized. Three recent reports document cholestatic jaundice and nephropathy due to these compounds. We present 3 additional cases of anabolic androgenic steroid-enriched dietary supplement-induced hepatotoxicity and 1 case of renal failure, and we review the literature and the relevant features of this growing health concern. Recognition of this entity could obviate the need for invasive diagnostic testing and hospitalization and facilitate diagnosis and appropriate counseling.

Publication types

  • Case Reports

MeSH terms

  • Adult
  • Anabolic Agents / adverse effects*
  • Androgens / adverse effects
  • Cholestasis, Intrahepatic / chemically induced*
  • Dietary Supplements / adverse effects*
  • Humans
  • Male
  • Renal Insufficiency / chemically induced*
  • Young Adult


  • Anabolic Agents
  • Androgens