The role of gene DCDC2 in German dyslexics

Ann Dyslexia. 2009 Jun;59(1):1-11. doi: 10.1007/s11881-008-0020-7. Epub 2009 Feb 24.


Dyslexia is a complex reading and writing disorder with a strong genetic component. In a German case-control cohort, we studied the influence of the suspected dyslexia-associated gene DCDC2. For the first time in a German cohort, we describe association of a 2445 basepair deletion, first identified in an American study. Evidence of association for three DCDC2 single nucleotide polymorphisms (rs807724, rs793862, rs807701), previously identified in German or American cohorts, was replicated. A haplotype of these polymorphisms showed evidence for association as well. Thus, our data further corroborate association of DCDC2 with dyslexia. Analysis of functional subgroups suggests association of investigated DCDC2 variants mainly with nondysphonetic, nonsevere, but probably dyseidetic (surface) dyslexia. Based on the presumed function of DCDC2, our findings point to a role of impaired neuronal migration in the etiology of the disease.

MeSH terms

  • Case-Control Studies
  • Child
  • Cohort Studies
  • Dyslexia / epidemiology
  • Dyslexia / genetics*
  • Germany / epidemiology
  • Humans
  • Microtubule-Associated Proteins / genetics*
  • Odds Ratio
  • Polymerase Chain Reaction
  • Polymorphism, Single Nucleotide / genetics
  • Severity of Illness Index


  • DCDC2 protein, human
  • Microtubule-Associated Proteins