The purpose of this study was to investigate the effect of protein tyrosine phosphatase 1B (PTP1B) inhibitors and taurine on blood lipid profiles of the obese adolescent. Three week-old thirty-six male Sprague-Dawley rats were randomly assigned to six groups (high fat diet (HFD) group, HFD group; high fat diet + taurine group, HFD + taurine (TR) group; high fat diet + PTP1B inhibitor A (A) group, HF + A group; high fat diet + PTP1B inhibitor B, HF + B group; high fat diet + PTP1B inhibitor A + taurine group, HF + A + TR group; and high fat diet + PTP1B inhibitor B + taurine group, HF+B+TR group). The body weight of the HF+A and HF + A + TR groups were significantly reduced compared to those of the other groups, the exception being the HF + B + TR group. Serum triglyceride (TG), total cholesterol (TC) and low density lipoprotein cholesterol (LDL-C) levels of the HF + A + TR group were significantly reduced compared to those of the other groups. However, serum high density lipoprotein cholesterol (HDL-C) levels in HF + B + TR group was significantly reduced compared those of the HFD and HF + TR groups. Therefore, these results suggest a possible effect of PTP1B inhibitors and taurine on blood triglyceride, total cholesterol and low density lipoprotein cholesterol in the obese adolescent.