Taurine normalizes blood levels and urinary loss of selenium, chromium, and manganese in rats chronically consuming alcohol

Adv Exp Med Biol. 2009;643:407-14. doi: 10.1007/978-0-387-75681-3_42.


The present study was undertaken to evaluate effects of dietary taurine supplementation on the homeostasis of trace elements, including Se, Cu, Mn and Cr, in rats chronically consuming alcohol. Male SD rats were fed for 8 wk a liquid form of a control diet (CD), an ethanol diet (ED), or a taurine-supplemented ethanol diet (TED). Plasma Se and Mn concentrations were significantly lower in the ED rats than in the CD rats; dietary taurine supplementation corrected alcohol-induced decreases in plasma Se and Mn levels. Chronic alcohol consumption significantly increased urinary excretion of Se (a 53% increase, p < 0.05), Cr (a 62% increase, p < 0.05), Mn (a 45% increase, p < 0.05) and Cu (a 30% increase, p < 0.05) in rats. Urinary losses of these trace elements induced by chronic alcohol consumption in rats were abolished by taurine supplementation. These results suggest that taurine supplementation in rats may protect against Se, Cr and Mn insufficiency caused by chronic alcohol-mediated loss of the trace elements in the urine.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Alcohol Drinking*
  • Animals
  • Chromium / analysis*
  • Chromium / blood
  • Chromium / urine
  • Ethanol / administration & dosage
  • Homeostasis / drug effects
  • Manganese / analysis*
  • Manganese / blood
  • Manganese / urine
  • Rats
  • Selenium / analysis*
  • Selenium / blood
  • Selenium / urine
  • Taurine / pharmacology*
  • Weight Gain / drug effects


  • Chromium
  • Taurine
  • Ethanol
  • Manganese
  • Selenium