mRNA Localization: Gene Expression in the Spatial Dimension

Cell. 2009 Feb 20;136(4):719-30. doi: 10.1016/j.cell.2009.01.044.

Abstract

The localization of mRNAs to subcellular compartments provides a mechanism for regulating gene expression with exquisite temporal and spatial control. Recent studies suggest that a large fraction of mRNAs localize to distinct cytoplasmic domains. In this Review, we focus on cis-acting RNA localization elements, RNA-binding proteins, and the assembly of mRNAs into granules that are transported by molecular motors along cytoskeletal elements to their final destination in the cell.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cytoplasm / metabolism
  • Humans
  • RNA Transport*
  • RNA, Messenger / metabolism*
  • RNA-Binding Proteins / metabolism
  • Regulatory Sequences, Ribonucleic Acid

Substances

  • RNA, Messenger
  • RNA-Binding Proteins
  • Regulatory Sequences, Ribonucleic Acid