Regulation of translation initiation in eukaryotes: mechanisms and biological targets

Cell. 2009 Feb 20;136(4):731-45. doi: 10.1016/j.cell.2009.01.042.

Abstract

Translational control in eukaryotic cells is critical for gene regulation during nutrient deprivation and stress, development and differentiation, nervous system function, aging, and disease. We describe recent advances in our understanding of the molecular structures and biochemical functions of the translation initiation machinery and summarize key strategies that mediate general or gene-specific translational control, particularly in mammalian systems.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Gene Expression Regulation*
  • Humans
  • Models, Molecular
  • Peptide Chain Initiation, Translational*
  • Peptide Initiation Factors / chemistry
  • Peptide Initiation Factors / metabolism
  • Ribosomes / chemistry
  • Ribosomes / metabolism

Substances

  • Peptide Initiation Factors