Migration, maintenance and recall of memory T cells in peripheral tissues

Nat Rev Immunol. 2009 Mar;9(3):153-61. doi: 10.1038/nri2496.


After the resolution of an immune response, antigen-specific memory T cells persist at many sites in the body. The antigen-specific memory T-cell pool includes memory T cells that preferentially reside in peripheral tissues, such as the skin, gut and lungs, where they provide a first line of defence against secondary pathogen infection. Determining how peripheral memory T cells are regulated is essential for our understanding of host-pathogen interactions and for vaccine development. In this Review, we discuss recent insights into the generation, control and recall of peripheral T-cell memory responses.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement
  • Communicable Diseases / immunology*
  • Host-Pathogen Interactions / immunology*
  • Humans
  • Immunity, Active
  • Immunologic Memory*
  • Intestines / immunology
  • Lung / immunology
  • Skin / immunology
  • Species Specificity
  • T-Lymphocytes / immunology
  • T-Lymphocytes / physiology*
  • Vaccines / immunology


  • Vaccines