The analytical method of famoxadone residue and its dissipation in grape and soil were investigated. Famoxadone (68.75% water-dispersible granule) was applied at two dosages (1.25 and 2.5 g l(-1)). Soil and grape samples were collected at intervals and analyzed for famoxadone residues. The results showed that the degradation rate of famoxadone in grape and soil were similar, and their dynamics could be described by C = 1.1738e (-0.0562t ) with correlation coefficient r = 0.9044 in grape and C = 5.6565e (-0.0515t ) with r = 0.9620 in soil, respectively. Half-lives were 12.3 and 13.5 days in grape and soil, respectively. The results indicated that at harvest time, the residues of famoxadone in grape were well below the EU's maximum residue level (2 mg kg(-1)) and was safe to apply in grape.