Whole-brain atrophy as a measure of progression in premanifest and early Huntington's disease

Mov Disord. 2009 Apr 30;24(6):932-6. doi: 10.1002/mds.22485.


Therapeutic trials in Huntington's disease (HD) are challenging as clinical progression is slow and variable and reliable biomarkers are lacking. We used magnetic resonance imaging and the brain boundary shift integral to quantify whole-brain atrophy rates over 1 year in early and premanifest HD subjects, and controls. Early HD subjects had statistically significantly (P = 0.007) increased (threefold higher) rates of whole-brain atrophy compared with controls. Higher atrophy rates were associated with longer CAG repeat length. MRI-based measures of whole-brain atrophy may have potential as a measure of progression in HD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Atrophy / etiology
  • Atrophy / pathology
  • Brain / pathology*
  • Brain Mapping
  • Disease Progression
  • Humans
  • Huntington Disease / complications
  • Huntington Disease / pathology*
  • Magnetic Resonance Imaging / methods
  • Middle Aged
  • Severity of Illness Index