Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

doi:10.1186/1743-7075-6-10

. 2009 Feb 26:6:10.

doi: 10.1186/1743-7075-6-10.

Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

Bryan D Kraft¹, Eric C Westman

Affiliations

PMID: 19245705
PMCID: PMC2652467
DOI: 10.1186/1743-7075-6-10

Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

Bryan D Kraft et al. Nutr Metab (Lond). 2009.

. 2009 Feb 26:6:10.

doi: 10.1186/1743-7075-6-10.

Authors

Bryan D Kraft¹, Eric C Westman

Affiliation

¹ Department of Medicine, Duke University Medical Center, NC, USA. bryan.kraft@duke.edu

PMID: 19245705
PMCID: PMC2652467
DOI: 10.1186/1743-7075-6-10

Abstract

We report the unexpected resolution of longstanding schizophrenic symptoms after starting a low-carbohydrate, ketogenic diet. After a review of the literature, possible reasons for this include the metabolic consequences from the elimination of gluten from the diet, and the modulation of the disease of schizophrenia at the cellular level.

PubMed Disclaimer

Cited by

The effects of ketogenic metabolic therapy on mental health and metabolic outcomes in schizophrenia and bipolar disorder: a randomized controlled clinical trial protocol.
Longhitano C, Finlay S, Peachey I, Swift JL, Fayet-Moore F, Bartle T, Vos G, Rudd D, Shareef O, Gordon S, Azghadi MR, Campbell I, Sethi S, Palmer C, Sarnyai Z. Longhitano C, et al. Front Nutr. 2024 Aug 21;11:1444483. doi: 10.3389/fnut.2024.1444483. eCollection 2024. Front Nutr. 2024. PMID: 39234289 Free PMC article.
Metabolic Insights into Neuropsychiatric Illnesses and Ketogenic Therapies: A Transcriptomic View.
Sahay S, Pulvender P, Rami Reddy MVSR, McCullumsmith RE, O'Donovan SM. Sahay S, et al. Int J Mol Sci. 2024 Jul 29;25(15):8266. doi: 10.3390/ijms25158266. Int J Mol Sci. 2024. PMID: 39125835 Free PMC article.
The Potential Role of the Ketogenic Diet in Serious Mental Illness: Current Evidence, Safety, and Practical Advice.
Rog J, Wingralek Z, Nowak K, Grudzień M, Grunwald A, Banaszek A, Karakula-Juchnowicz H. Rog J, et al. J Clin Med. 2024 May 10;13(10):2819. doi: 10.3390/jcm13102819. J Clin Med. 2024. PMID: 38792361 Free PMC article. Review.
The impact of ketogenic diet on some metabolic and non-metabolic diseases: Evidence from human and animal model experiments.
Galali Y, Zebari SMS, Aj Jabbar A, Hashm Balaky H, Sadee BA, Hassanzadeh H. Galali Y, et al. Food Sci Nutr. 2024 Jan 8;12(3):1444-1464. doi: 10.1002/fsn3.3873. eCollection 2024 Mar. Food Sci Nutr. 2024. PMID: 38455178 Free PMC article. Review.
The Relationship of Ketogenic Diet with Neurodegenerative and Psychiatric Diseases: A Scoping Review from Basic Research to Clinical Practice.
Mentzelou M, Dakanalis A, Vasios GK, Gialeli M, Papadopoulou SK, Giaginis C. Mentzelou M, et al. Nutrients. 2023 May 11;15(10):2270. doi: 10.3390/nu15102270. Nutrients. 2023. PMID: 37242153 Free PMC article. Review.

See all "Cited by" articles

References

1. Yancy WS, Jr, Olsen MK, Guyton JR, Bakst RP, Westman EC. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004;140:769–777. - PubMed
1. Dohan FC. Cereals and schizophrenia data and hypothesis. Acta Psych Scand. 1966;42:125–152. doi: 10.1111/j.1600-0447.1966.tb01920.x. - DOI - PubMed
1. Dohan FC, Harper EH, Clark MH, Rodrigue RB, Zigas V. Is schizophrenia rare if grain is rare? Biol Psychiatry. 1984;19:385–399. - PubMed
1. Kalaydjian AE, Eaton W, Cascella N, Fasano A. The gluten connection: the association between schizophrenia and celiac disease. Acta Psychiatr Scand. 2006;113:82–90. doi: 10.1111/j.1600-0447.2005.00687.x. - DOI - PubMed
1. Vlissides DN, Venulet A, Jenner FA. A double-blind gluten-free/gluten-load controlled trial in a secure ward population. Br J Psych. 1986;148:447–452. doi: 10.1192/bjp.148.4.447. - DOI - PubMed

LinkOut - more resources

Full Text Sources

[1] Yancy WS, Jr, Olsen MK, Guyton JR, Bakst RP, Westman EC. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004;140:769–777. - PubMed

[2] Yancy WS, Jr, Olsen MK, Guyton JR, Bakst RP, Westman EC. A low-carbohydrate, ketogenic diet versus a low-fat diet to treat obesity and hyperlipidemia: a randomized, controlled trial. Ann Intern Med. 2004;140:769–777. - PubMed

[3] Dohan FC. Cereals and schizophrenia data and hypothesis. Acta Psych Scand. 1966;42:125–152. doi: 10.1111/j.1600-0447.1966.tb01920.x. - DOI - PubMed

[4] Dohan FC. Cereals and schizophrenia data and hypothesis. Acta Psych Scand. 1966;42:125–152. doi: 10.1111/j.1600-0447.1966.tb01920.x. - DOI - PubMed

[5] Dohan FC, Harper EH, Clark MH, Rodrigue RB, Zigas V. Is schizophrenia rare if grain is rare? Biol Psychiatry. 1984;19:385–399. - PubMed

[6] Dohan FC, Harper EH, Clark MH, Rodrigue RB, Zigas V. Is schizophrenia rare if grain is rare? Biol Psychiatry. 1984;19:385–399. - PubMed

[7] Kalaydjian AE, Eaton W, Cascella N, Fasano A. The gluten connection: the association between schizophrenia and celiac disease. Acta Psychiatr Scand. 2006;113:82–90. doi: 10.1111/j.1600-0447.2005.00687.x. - DOI - PubMed

[8] Kalaydjian AE, Eaton W, Cascella N, Fasano A. The gluten connection: the association between schizophrenia and celiac disease. Acta Psychiatr Scand. 2006;113:82–90. doi: 10.1111/j.1600-0447.2005.00687.x. - DOI - PubMed

[9] Vlissides DN, Venulet A, Jenner FA. A double-blind gluten-free/gluten-load controlled trial in a secure ward population. Br J Psych. 1986;148:447–452. doi: 10.1192/bjp.148.4.447. - DOI - PubMed

[10] Vlissides DN, Venulet A, Jenner FA. A double-blind gluten-free/gluten-load controlled trial in a secure ward population. Br J Psych. 1986;148:447–452. doi: 10.1192/bjp.148.4.447. - DOI - PubMed

Save citation to file

Email citation

Add to Collections

Add to My Bibliography

Your saved search

Create a file for external citation management software

Your RSS Feed

Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

Affiliation

Schizophrenia, gluten, and low-carbohydrate, ketogenic diets: a case report and review of the literature

Authors

Affiliation

Abstract

Similar articles

Cited by

References

LinkOut - more resources

Full Text Sources

Abstract

Similar articles

Cited by

References

Related information

LinkOut - more resources

Full Text Sources