[Therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats]

Nan Fang Yi Ke Da Xue Xue Bao. 2009 Feb;29(2):264-6.
[Article in Chinese]


Objective: To study the therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats.

Methods: The rats bearing implanted Walker-256 hepatoma were treated with high-dose vitamin C at 2.83 and 5.65 g/kg intravenously, and the general condition, liver functions (A/G, ALT, AST, GGT), tumor volume, and tumor growth of the rats were evaluated.

Results: The A/G of the rats treated with 2.83 g/kg vitamin C was significantly higher, but the ALT and GCT were significantly lower than those of the model rats (P<0.05 or 0.01). The ALT level in rats with 5.65 g/kg vitamin C treatment was significantly lower than that of the model rats (P<0.05). The tumor necrosis rate was significantly higher in rats with 2.83 g/kg vitamin C treatment than in the model rats (P<0.05).

Conclusion: Intravenous administration of 2.83 g/kg vitamin C can promote the necrosis and apoptosis of hepatoma Walker256 cells in rats and protect the liver function of the tumor-bearing rats.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Apoptosis / drug effects*
  • Ascorbic Acid / administration & dosage*
  • Injections, Intravenous
  • Liver Neoplasms, Experimental / drug therapy*
  • Liver Neoplasms, Experimental / pathology
  • Male
  • Necrosis
  • Neoplasm Transplantation
  • Rats
  • Rats, Sprague-Dawley
  • Rats, Wistar


  • Ascorbic Acid