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. 2009 Feb;29(2):264-6.

[Therapeutic Effect of Intravenous High-Dose Vitamin C on Implanted Hepatoma in Rats]

[Article in Chinese]
Affiliations
  • PMID: 19246295

[Therapeutic Effect of Intravenous High-Dose Vitamin C on Implanted Hepatoma in Rats]

[Article in Chinese]
Lin-ji Peng et al. Nan Fang Yi Ke Da Xue Xue Bao. .

Abstract

Objective: To study the therapeutic effect of intravenous high-dose vitamin C on implanted hepatoma in rats.

Methods: The rats bearing implanted Walker-256 hepatoma were treated with high-dose vitamin C at 2.83 and 5.65 g/kg intravenously, and the general condition, liver functions (A/G, ALT, AST, GGT), tumor volume, and tumor growth of the rats were evaluated.

Results: The A/G of the rats treated with 2.83 g/kg vitamin C was significantly higher, but the ALT and GCT were significantly lower than those of the model rats (P<0.05 or 0.01). The ALT level in rats with 5.65 g/kg vitamin C treatment was significantly lower than that of the model rats (P<0.05). The tumor necrosis rate was significantly higher in rats with 2.83 g/kg vitamin C treatment than in the model rats (P<0.05).

Conclusion: Intravenous administration of 2.83 g/kg vitamin C can promote the necrosis and apoptosis of hepatoma Walker256 cells in rats and protect the liver function of the tumor-bearing rats.

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