Moving or stopping mitochondria: Miro as a traffic cop by sensing calcium

Neuron. 2009 Feb 26;61(4):493-6. doi: 10.1016/j.neuron.2009.02.003.

Abstract

Mitochondrial transport in neurons and their spatial distribution among synapses are directly correlated with synaptic activity. One paper in this issue of Neuron (MacAskill et al.) and two papers recently published in Cell (Wang and Schwarz) and PNAS (Saotome et al.) provide compelling evidence that Miro serves as a calcium sensor that controls mitochondrial mobility.

Publication types

  • Comment
  • Research Support, N.I.H., Intramural

MeSH terms

  • Animals
  • Drosophila / physiology
  • Drosophila Proteins / physiology*
  • Mitochondria / physiology*
  • Nerve Tissue Proteins / physiology
  • Neurons / physiology
  • Receptors, Calcium-Sensing / physiology*
  • Synapses / physiology
  • rho GTP-Binding Proteins / physiology*

Substances

  • Drosophila Proteins
  • Nerve Tissue Proteins
  • Receptors, Calcium-Sensing
  • milt protein, Drosophila
  • Miro protein, Drosophila
  • rho GTP-Binding Proteins