Effect of different MCT/LCT ratios on protein synthesis in injured rats fed parenterally

Rev Esp Fisiol. 1991 Jun;47(2):81-6.


The effect of the lipidic composition of the diet on the proteic synthesis of the male Sprague-Dawley rats fed parenterally for four days has been studied. All animals received identical nitrogen and caloric intake, but the ratio of medium to long-chain triglycerides (MCT/LCT) varied: group 1, control (0/100); group 2 (30/70); group 3 (50/50) and group 4 (70/30). Hepatic and jejunal protein synthesis were determined with L-(1-14C)-leucine. In groups 1, 3 and 4 muscle protein synthesis was measured with L-(3,4-3H)-phenylalanine. In liver, there were no significant differences in the fractional synthesis rate among the groups. In jejunum, the control group showed a higher fractional synthesis rate with statistically significant differences among the groups. In muscle, group 3 presented the highest fractional synthesis rate with statistically significant differences (p less than 0.05).

MeSH terms

  • Animals
  • Energy Intake
  • Jejunum / metabolism
  • Liver / metabolism
  • Male
  • Muscle Proteins / biosynthesis
  • Nitrogen / metabolism
  • Parenteral Nutrition*
  • Protein Biosynthesis*
  • Rats
  • Stress, Physiological / metabolism*
  • Triglycerides / chemistry
  • Triglycerides / metabolism*


  • Muscle Proteins
  • Triglycerides
  • Nitrogen