Botulinum toxin cosmetic therapy correlates with a more positive mood

J Cosmet Dermatol. 2009 Mar;8(1):24-6. doi: 10.1111/j.1473-2165.2009.00419.x.


Background: It has been suggested that botulinum toxin A (BTX-A) treatment for frown lines can also be used as a treatment for depression. A psychological mechanism for this effect is reviewed in which paralysis of the corrugator (frown) muscles leads to less facial feedback for negative emotions. Consequently, a negative affect is harder to maintain and so the person has a more positive mood.

Methods: In order to test this mechanism, the mood of patients who had received BTX-A treatment for glabelar frown lines was measured and compared with patients who had received other cosmetic treatments.

Results: The BTX-A-treated patients showed significantly less negative mood.

Conclusion: The results support the facial feedback view that frowning can make one unhappier. Treatments that prevent frowning correlate with reduced negative mood.

Publication types

  • Evaluation Study

MeSH terms

  • Affect*
  • Aging / psychology
  • Botulinum Toxins, Type A / therapeutic use*
  • Case-Control Studies
  • Cosmetic Techniques / psychology
  • Esthetics
  • Female
  • Follow-Up Studies
  • Humans
  • Injections, Subcutaneous
  • Middle Aged
  • Patient Satisfaction
  • Probability
  • Rejuvenation / psychology*
  • Self Concept*
  • Skin Aging / drug effects*
  • Stress, Psychological
  • Time Factors
  • Treatment Outcome


  • Botulinum Toxins, Type A