Whether magnetic resonance imaging (MRI) or ultrasound (US) are chosen for the purposes of musculoskeletal interrogation depends upon a variety of factors ranging from the anatomy targeted to cost considerations and the time of acquisition. Newer technologies such as higher-strength MRI or 3D-US promise to help overcome some of the disadvantages of each option. Improving technical proficiency is the thrust of efforts to support more widespread application of sonographic assessment in various clinical arenas. Finally, these technologies offer the opportunity to diagnose inflammatory conditions at early stages of their disease progression.