This chapter presents a regional anatomic approach to MRI applications in the foot and ankle. From a clinical perspective, patients often describe their symptoms in terms of the part of the foot that hurts and when and how it hurts. Clinical questioning and physical diagnosis pursue this line as well, trying to narrow down the diagnostic possibilities. There are conditions that may blur the anatomic distinctions for forefoot, midfoot, rearfoot, and ankle; involve more than one region of the foot simultaneously; or occur in any area of the foot. The chapter also includes a separate section on the presentations of inflammatory arthritides in foot and ankle joints.