Synopsis Alpha-hydroxy acids are a common class of naturally occurring chemicals that have become increasingly popular for cosmetic use. Currently alpha-hydroxy acids from both natural and synthetic sources are being used in skincare products. From lactic acid to complex natural blends, several different approaches have been adopted for the use of alpha-hydroxy acids. This paper reviews the history of alpha-hydroxy acids use in cosmetics and gives new data showing the increased rate of cell renewal by topical application.